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Cloud Alpha
Family
overview
VITROCELL ® Cloud Alpha
VITROCELL ® 노출 시스템은 가스, 복잡한 혼합물, 나노입자 및 섬유와 같은 공기 중 물질에 직접 노출되는 박테리아에 대한 연구를 용이하게 하도록 특별히 설계 및 제작되었습니다. 이 시스템은 인간의 생리적 노출 조건을 확실하게 시뮬레이션합니다
VITROCELL CLOUD ALPHA 6
VITROCELL ® Cloud Alpha 6는 클라우드 제품군의 혁신 제품이며 세포 배양의 자동화된 노출에서 큰 도약을 제시합니다. 높은 증착 효율과 사용 편의성을 결합합니다. 이 개발은 1세대의 잘 알려지고 자주 게시되는 VITROCELL ® 클라우드 형식(6, 12 및 24웰) 을 기반으로 합니다 . 이 기능은 올인원 제어 장치로 완전히 자동화된 프로세스를 가능하게 합니다. 공기/액체 인터페이스 (ALI) 에서의 일상적인 실험이 그 어느 때보다 쉬워졌습니다.
Cloud Alpha 6는 수많은 고객 요청의 결과로 개발되었으며 6, 12 또는 24웰 크기의 세포 배양 삽입물에서 포유류 세포 배양을 노출할 수 있습니다. 모든 상용 브랜드가 지원됩니다.
클라우드 시스템은 용액 및 현탁액의 분무화에 적합합니다. 응용 분야는 바이러스 연구, 흡입 약물 스크리닝 및 화학 물질이나 나노 입자와 같은 흡입 물질의 독성 테스트입니다.
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Exposure at the Air/Liquid Interface
Air/Liquid Cultivation
and Exposure in Exposure Module
A: Direct and controlled exposure of test atmosphere to cells
B: Cells on membrane
C: Media below cells
In response to the scientific need to expose in physiologically relevant conditions, the VITROCELL® Cloud Alpha exposure devices have been specifically designed to enable direct exposure of mammalian cells or tissue at the Air/Liquid Interface. Here the cell cultures are not covered with media as opposed to submerged conditions which cause an undesired interaction of the formerly airborne substances with the culture media.
Cell systems cultivated on membrane inserts are exposed at the Air/Liquid Interface (ALI) so that the test substances are received directly. This approach allows for more credible and authentic results than by submerged exposure due to a closer replication of the human physiology.
How the Vitrocell Cloud works
After pipetting the suspension, exposure to the cell cultures takes place in three phases:
Phase 1: Emission Of Cloud
Phase 2: Homogeneous Mixing
Phase 3: Gravitational Settling
Insert holder system
Insert holders for 6-, 12- and 24-well sized inserts are part of the delivery. All commercial brands are supported.
6-well
12-well
24-well
More about VITROCELL Cloud Alpha 6
Dosimetry using Quartz Crystal Microbalance (QCM)
The QCM sensor is integrated in the Cloud Alpha 6 exposure module. It is capable of measuring the deposited mass at a resolution of 10 nanogram/cm2 per second. Results are reported online by the VITROCELL Monitor Software. Data is presented in graphs and stored in MS Excel®.
Different choices of nebulizers
The system comes with a choice of 3 types of vibrating mesh nebulizers having droplet MMAD ranges of 2.5 – 6.0 µm, 2.5 – 4.0 µm and 4.0 – 6.0 µm.
Recommended nebulisation volumes are 200 µl. So the device is particularly suitable for testing whenever small quantities of testing materials are available.
Features
-
Integrated controller for aerosol generator
-
Optional integrated microbalance controller
-
Defined experiment recipes
-
Automatisation of the experiment by nebulization time or by user-defined volume
-
Output rate database for nebulizers
-
Heating system
-
Optional PowerVent function: evacuation of potentially residual aerosols via vacuum pump
-
Designed for virus research, screening of inhaled drugs and toxicity testing of inhaled substances such as chemicals or nanoparticles
VITROCELL Cloud Alpha 12
VITROCELL ® Cloud Alpha 12는 클라우드 제품군의 혁신이며 세포 배양의 자동화된 노출에서 큰 도약을 제시합니다. 높은 증착 효율과 사용 편의성을 결합합니다. 이 개발은 1세대의 잘 알려지고 자주 게시되는 VITROCELL ® 클라우드 형식(12 및 24웰)을 기반으로 합니다. 이 기능은 올인원 제어 장치로 완전히 자동화된 프로세스를 가능하게 합니다. 공기/액체 인터페이스 (ALI) 에서의 일상적인 실험이 그 어느 때보다 쉬워졌습니다.
Cloud Alpha 12는 수많은 고객 요청의 결과로 개발되었으며 12 또는 24웰 크기의 세포 배양 삽입물에서 포유류 세포 배양을 노출할 수 있습니다. 모든 상용 브랜드가 지원됩니다.
클라우드 시스템은 용액 및 현탁액의 분무화에 적합합니다. 응용 분야는 바이러스 연구, 흡입 약물 스크리닝 및 화학 물질이나 나노 입자와 같은 흡입 물질의 독성 테스트입니다.
Exposure at the Air/Liquid Interface
Air/Liquid Cultivation
and Exposure in Exposure Module
A: Direct and controlled exposure of test atmosphere to cells
B: Cells on membrane
C: Media below cells
In response to the scientific need to expose in physiologically relevant conditions, the VITROCELL® Cloud Alpha exposure devices have been specifically designed to enable direct exposure of mammalian cells or tissue at the Air/Liquid Interface. Here the cell cultures are not covered with media as opposed to submerged conditions which cause an undesired interaction of the formerly airborne substances with the culture media.
Cell systems cultivated on membrane inserts are exposed at the Air/Liquid Interface (ALI) so that the test substances are received directly. This approach allows for more credible and authentic results than by submerged exposure due to a closer replication of the human physiology.
How the Vitrocell Cloud works
After pipetting the suspension, exposure to the cell cultures takes place in two steps, each with three phases:
Step 1- Clean Air control
Phase 1: Emission Of Cloud
Phase 2: Homogeneous Mixing
Phase 3: Gravitational Settling
Step 2 - Test Aerosol
Phase 1: Emission Of Cloud
Phase 2: Homogeneous Mixing
Phase 3: Gravitational Settling
Insert holder system
Insert holders for 12- and 24-well sized inserts are part of the delivery. All commercial brands are supported.
More about VITROCELL Cloud Alpha 12
Dosimetry using Quartz Crystal Microbalance (QCM)
The QCM sensor is integrated in the Cloud Alpha 6 exposure module. It is capable of measuring the deposited mass at a resolution of 10 nanogram/cm2 per second. Results are reported online by the VITROCELL Monitor Software. Data is presented in graphs and stored in MS Excel®.
Different choices of nebulizers
The system comes with a choice of 3 types of vibrating mesh nebulizers having droplet MMAD ranges of 2.5 – 6.0 µm, 2.5 – 4.0 µm and 4.0 – 6.0 µm.
Recommended nebulisation volumes are 200 µl. So the device is particularly suitable for testing whenever small quantities of testing materials are available.
Features
-
Integrated controller for aerosol generator
-
Optional integrated microbalance controller
-
Defined experiment recipes
-
Automatisation of the experiment by nebulization time or by user-defined volume
-
Output rate database for nebulizers
-
Heating system
-
Optional PowerVent function: evacuation of potentially residual aerosols via vacuum pump
-
Designed for virus research, screening of inhaled drugs and toxicity testing of inhaled substances such as chemicals or nanoparticles
VITROCELL Cloud Alpha 96
VITROCELL ® Cloud Alpha 96은 우리의 혁신이며 공기/액체 인터페이스 (ALI) 에서 세포 배양의 자동화된 노출에서 큰 도약을 제시합니다 . 높은 처리량 테스트와 사용 편의성을 결합합니다. 이 개발은 잘 알려져 있고 자주 게시되는 VITROCELL ® 클라우드 형식(6, 12 및 24웰)을 기반으로 합니다. 이 기능은 올인원 제어 장치로 완전히 자동화된 프로세스를 가능하게 합니다. 공기/액체 인터페이스에서의 일상적인 실험이 그 어느 때보다 쉬워졌습니다.
새로운 Cloud Alpha 96 시리즈는 수많은 고객 요청의 결과로 개발되었으며 이제 Corning ® HTS Transwell ® 96-웰 투과 지원 시스템 에서 포유류 세포 배양을 노출할 수 있습니다 .
클라우드 시스템은 용액 및 현탁액의 분무화에 적합합니다. 가능한 응용 분야는 흡입 약물의 스크리닝, 화학 물질 또는 나노 입자와 같은 흡입 물질의 독성 테스트 및 바이러스 연구입니다.
Exposure at the Air/Liquid Interface
Air/Liquid Cultivation
and Exposure in Exposure Module
A: Direct and controlled exposure of test atmosphere to cells
B: Cells on membrane
C: Media below cells
In response to the scientific need to expose in physiologically relevant conditions, the VITROCELL® Cloud Alpha exposure devices have been specifically designed to enable direct exposure of mammalian cells or tissue at the Air/Liquid Interface. Here the cell cultures are not covered with media as opposed to submerged conditions which cause an undesired interaction of the formerly airborne substances with the culture media.
Cell systems cultivated on membrane inserts are exposed at the Air/Liquid Interface (ALI) so that the test substances are received directly. This approach allows for more credible and authentic results than by submerged exposure due to a closer replication of the human physiology.
More about VITROCELL Cloud Alpha 96
VITROCELL Cloud Alpha 96
VITROCELL Cloud Alpha 96 +
Cloud Alpha 96 + with integrated Quartz Crystal Microbalance (QCM)
Two Versions available
The system is available as Cloud Alpha 96 and Cloud Alpha 96+. The latter features an integrated Quartz Crystal Microbalance for online assessment of the deposited mass.
Choice of three types of nebulizers
The system comes with a choice of 3 types of vibrating mesh nebulizers having droplet MMAD ranges of 2.5 – 6.0 µm, 2.5 – 4.0 µm and 4.0 – 6.0 µm.
Recommended nebulisation volumes are 200 µl (Cloud Alpha 96) and 300 µl (Cloud Alpha 96+). So the device is particularly suitable for testing whenever small quantitities of testing materials are available.
Corning HTS Transwell 96-well Plate
.
Dosimetry using Quartz Crystal Microbalance (QCM)
The QCM sensor is integrated in the Cloud Alpha 96+ exposure module. It is capable of measuring the deposited mass at a resolution of 10 nanogram/cm2 per second. Results are reported online by the VITROCELL Monitor software. Data is presented in graphs and stored in MS Excel®.
Features
-
Integrated controller for aerosol generator
-
Optional integrated microbalance controller
-
Defined experiment recipes
-
Automatisation of the experiment by nebulization time or by user-defined volume
-
Output rate database for nebulizers
-
Heating system
-
Optional PowerVent function: evacuation of potentially residual aerosols via vacuum pump
-
Designed for virus research, screening of inhaled drugs and toxicity testing of inhaled substances such as chemicals or nanoparticles