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Highest Throughput
The VITROCELL® Highest Throughput Exposure Systems are designed to maximize efficiency and capacity in inhalation toxicology studies. They support a large number of samples simultaneously, enabling extensive and detailed analysis. These systems are particularly attractive to customers because they provide high-volume data collection, reducing time and costs associated with large-scale toxicological assessments while maintaining accuracy and reliability.
VITROCELL® 24/48 Exposure System
for 48 cell culture inserts (24-well size)
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VITROCELL® 48/48 Plus Exposure System
for 35 mm Petri dishes
VITROCELL® 96
for 96-well HTS plates
1. Docking Station for Base Module and Exposure Top
The docking station guarantees a hermetic connection of the base module with the aerosol exposure top. The flow rate for each of the 96 inlets is controlled by critical orifices which are connected to a vacuum pump.
2. Quick-lock Dilution Systems
The integrated 12-fold dilution system can be easily separated from the exposure head for cleaning and maitenance.
Performance Qualification
The system was evaluated in a comprehensive performance qualification using combustion cigarette aerols. As a conclusion, the system is fit for purpose.
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11 Dilution Steps: 0,5–8 l/min Air
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Cigarettes: 1R6F
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Smoking Regime: Health Canada
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Puff number: 5 Cigarettes à 8 puffs
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Puff volume: 55 ml
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Puff duration: 2s
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Exhaust duration: 8s
Continuous Flow:
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Assay: Autofluorescence
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Trapping Liquid: DMSO
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Trapping Volume: 96-well 60 μL
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Vitrocell SOP: QMD-70- 39
Features
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Base module for 96-well HTS plates
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12-fold Dilution/Distribution System
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12 mass flow controllers for humidified air
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11 dilutions @ 8 replicates
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1 clean air control @ 8 replicates
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Electronic heating system for base module and exposure head
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Exposure head with 96 critical orifices and filter system
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Climatic Chamber for condensation-free operation if using liquid aerosols
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Housing with double-doors
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Heating systems with two RH/T sensors for temperature monitoring
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Software for read-out of sensor data to controller
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Integrated humidification system